› 4ejq

X-ray diffraction
1.89Å resolution

Crystal structure of KIF1A C-CC1-FHA

Released:
DOI: 10.2210/pdb4ejq/pdb
PDB entry 4ejq coloured by chain, front view.
PDB entry 4ejq coloured by chain, side view.
PDB entry 4ejq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A.
Huo L, Yue Y, Ren J, Yu J, Liu J, Yu Y, Ye F, Xu T, Zhang M, Feng W
Structure 20 1550-61 (2012)
PMID: 22863567

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171389 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF1A Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 154 amino acids
Theoretical weight: 17.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12756 (Residues: 458-607; Coverage: 9%)
Gene names: ATSV, C2orf20, KIF1A
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P1
Unit cell:
a: 42.945Å b: 57.844Å c: 110.394Å
α: 89.98° β: 89.96° γ: 90.63°
R-values:
R R work R free
0.188 0.187 0.231
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance.
Prokop A. (2013)
5 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)