› 4eku

X-ray diffraction
3.25Å resolution

Crystal Structure of FERM Domain of Proline-rich Tyrosine Kinase 2

Released:
DOI: 10.2210/pdb4eku/pdb
PDB entry 4eku coloured by chain, front view.
PDB entry 4eku coloured by chain, side view.
PDB entry 4eku coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Savarimuthu B, Li R, Wang Y

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-171983 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-tyrosine kinase 2-beta Chain: A
Molecule details ›
Chain: A
Length: 392 amino acids
Theoretical weight: 45.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14289 (Residues: 21-409; Coverage: 39%)
Gene names: FAK2, PTK2B, PYK2, RAFTK
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3221
Unit cell:
a: 112.971Å b: 112.971Å c: 103.335Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.186 0.212
Expression system: Escherichia coli BL21(DE3)

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