› 4elj

X-ray diffraction
2.7Å resolution

Crystal structure of the inactive retinoblastoma protein phosphorylated at T373

Released:
DOI: 10.2210/pdb4elj/pdb
PDB entry 4elj coloured by chain, front view.
PDB entry 4elj coloured by chain, side view.
PDB entry 4elj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control.
Burke JR, Hura GL, Rubin SM
Genes Dev 26 1156-66 (2012)
PMID: 22569856

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoblastoma-associated protein Chain: A
Molecule details ›
Chain: A
Length: 656 amino acids
Theoretical weight: 76.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06400 (Residues: 53-787; Coverage: 70%)
Gene name: RB1
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 51.62Å b: 129.51Å c: 135.04Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.212 0.266
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

24 review citations

Molecular mechanisms underlying RB protein function.
Dick et al. (2013)
23 more

9 mentions without citation

Deciphering the retinoblastoma protein phosphorylation code.
Rubin SM. (2013)
8 more