› 4ell

X-ray diffraction
1.98Å resolution

Structure of the inactive retinoblastoma protein pocket domain

Released:
DOI: 10.2210/pdb4ell/pdb
PDB entry 4ell coloured by chain, front view.
PDB entry 4ell coloured by chain, side view.
PDB entry 4ell coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control.
Burke JR, Hura GL, Rubin SM
Genes Dev 26 1156-66 (2012)
PMID: 22569856

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoblastoma-associated protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 411 amino acids
Theoretical weight: 47.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06400 (Residues: 380-787; Coverage: 44%)
Gene name: RB1
Sequence domains:
Structure domains: Cyclin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: R3
Unit cell:
a: 249.659Å b: 249.659Å c: 35.11Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.193 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

25 review citations

Molecular mechanisms underlying RB protein function.
Dick et al. (2013)
24 more

6 mentions without citation

Deciphering the retinoblastoma protein phosphorylation code.
Rubin SM. (2013)
5 more