› 4ema

X-ray diffraction
2.54Å resolution

Human peroxisome proliferator-activated receptor gamma in complex with rosiglitazone

Released:
DOI: 10.2210/pdb4ema/pdb
PDB entry 4ema coloured by chain, front view.
PDB entry 4ema coloured by chain, side view.
PDB entry 4ema coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists.
Liberato MV, Nascimento AS, Ayers SD, Lin JZ, Cvoro A, Silveira RL, Martínez L, Souza PC, Saidemberg D, Deng T, Amato AA, Togashi M, Hsueh WA, Phillips K, Palma MS, Neves FA, Skaf MS, Webb P, Polikarpov I
PLoS One 7 e36297 (2012)
PMID: 22649490

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 275 amino acids
Theoretical weight: 31.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand BRL 1 x BRL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: C2
Unit cell:
a: 90.511Å b: 61.958Å c: 117.601Å
α: 90° β: 100.7° γ: 90°
R-values:
R R work R free
0.182 0.18 0.225
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Short- and medium-chain fatty acids in energy metabolism: the cellular perspective.
Schönfeld et al. (2016)
17 more

34 mentions without citation

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.
Wang et al. (2014)
33 more