› 4en0

X-ray diffraction
2.59Å resolution

Crystal structure of light

Released:
DOI: 10.2210/pdb4en0/pdb
PDB entry 4en0 coloured by chain, front view.
PDB entry 4en0 coloured by chain, side view.
PDB entry 4en0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Liu W, Zhan C, Cheng H, Kumar PR, Bonanno JB, Nathenson SG, Almo SC
Structure 22 1252-1262 (2014)
PMID: 25087510

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 14, soluble form Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 167 amino acids
Theoretical weight: 18.43 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: O43557 (Residues: 83-240; Coverage: 66%)
Gene names: HVEML, LIGHT, TNFSF14, UNQ391/PRO726
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand PO4 1 x PO4
Ligand GOL 1 x GOL
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: I212121
Unit cell:
a: 94.699Å b: 99.981Å c: 124.382Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.286
Expression system: Drosophila

Quick links

Citations

5 review citations

The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses.
Ward-Kavanagh et al. (2016)
4 more

3 mentions without citation

Dimerization of LTβR by LTα1β2 is necessary and sufficient for signal transduction.
Sudhamsu et al. (2013)
2 more