› 4eo7

X-ray diffraction
1.45Å resolution

Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88.

Released:
DOI: 10.2210/pdb4eo7/pdb
PDB entry 4eo7 coloured by chain, front view.
PDB entry 4eo7 coloured by chain, side view.
PDB entry 4eo7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.
Snyder GA, Cirl C, Jiang J, Chen K, Waldhuber A, Smith P, Römmler F, Snyder N, Fresquez T, Dürr S, Tjandra N, Miethke T, Xiao TS
Proc Natl Acad Sci U S A 110 6985-90 (2013)
PMID: 23569230

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189282 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myeloid differentiation primary response protein MyD88 Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99836 (Residues: 157-296; Coverage: 47%)
Gene name: MYD88
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 34.876Å b: 56.81Å c: 66.664Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.208
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains.
Ve et al. (2015)
8 more

13 mentions without citation

Structural and functional understanding of the toll-like receptors.
Asami et al. (2021)
12 more