4eow

X-ray diffraction
1.97Å resolution

Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-134832 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 1 Chain: H
Molecule details ›
Chain: H
Length: 228 amino acids
Theoretical weight: 24.57 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01857 (Residues: 1-101; Coverage: 25%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunoglobulin lambda constant 2 Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P0DOY2 (Residues: 1-106; Coverage: 100%)
Gene name: IGLC2
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 67.289Å b: 47.786Å c: 159.244Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.224 0.257
Expression system: Cricetulus griseus