› 4eyc

X-ray diffraction
1.9Å resolution

Crystal structure of the cathelin-like domain of human cathelicidin LL-37 (hCLD)

Released:
DOI: 10.2210/pdb4eyc/pdb
PDB entry 4eyc coloured by chain, front view.
PDB entry 4eyc coloured by chain, side view.
PDB entry 4eyc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of the pro-domain of human cathelicidin, LL-37.
Pazgier M, Ericksen B, Ling M, Toth E, Shi J, Li X, Galliher-Beckley A, Lan L, Zou G, Zhan C, Yuan W, Pozharski E, Lu W
Biochemistry 52 1547-58 (2013)
PMID: 23406372

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156078 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antibacterial peptide FALL-39 Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 11.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49913 (Residues: 31-133; Coverage: 74%)
Gene names: CAMP, CAP18, FALL39, HSD26
Sequence domains: Cathelicidin
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P21212
Unit cell:
a: 91.146Å b: 57.987Å c: 39.546Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.242
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Antiviral drug discovery: broad-spectrum drugs from nature.
Martinez et al. (2015)
4 more

3 mentions without citation

The antimicrobial peptides and their potential clinical applications.
Lei et al. (2019)
2 more