› 4eyj

X-ray diffraction
2.1Å resolution

MAPK13 Complex with inhibitor

Released:
DOI: 10.2210/pdb4eyj/pdb
PDB entry 4eyj coloured by chain, front view.
PDB entry 4eyj coloured by chain, side view.
PDB entry 4eyj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.
Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ
J Clin Invest 122 4555-68 (2012)
PMID: 23187130

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 13 Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 42.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15264 (Residues: 1-352; Coverage: 96%)
Gene names: MAPK13, PRKM13, SAPK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand N61 1 x N61
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 60.855Å b: 69.955Å c: 92.807Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.242 0.275
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Respiratory epithelial cells orchestrate pulmonary innate immunity.
Whitsett et al. (2015)
26 more

8 mentions without citation

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase.
Smith et al. (2019)
7 more