› 4eza

X-ray diffraction
1.5Å resolution

Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2

Released:
DOI: 10.2210/pdb4eza/pdb
PDB entry 4eza coloured by chain, front view.
PDB entry 4eza coloured by chain, side view.
PDB entry 4eza coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.
Dixon MJ, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, Nedyalkova L, Park HW, Leslie NR, van Aalten DM, Downes CP, Batty IH
J Biol Chem 287 22483-96 (2012)
PMID: 22493426

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras GTPase-activating-like protein IQGAP2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 114 amino acids
Theoretical weight: 13.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q13576 (Residues: 1476-1571; Coverage: 6%)
Gene name: IQGAP2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 45.067Å b: 47.234Å c: 46.631Å
α: 90° β: 95.51° γ: 90°
R-values:
R R work R free
0.21 0.21 0.239
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

Phosphoinositides: tiny lipids with giant impact on cell regulation.
Balla T. (2013)
6 more

2 mentions without citation

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.
Dixon et al. (2012)
1 more