› 4f0i

X-ray diffraction
2.3Å resolution

Crystal structure of apo TrkA

Released:
DOI: 10.2210/pdb4f0i/pdb
PDB entry 4f0i coloured by chain, front view.
PDB entry 4f0i coloured by chain, side view.
PDB entry 4f0i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structures of TrkA and TrkB suggest key regions for achieving selective inhibition.
Bertrand T, Kothe M, Liu J, Dupuy A, Rak A, Berne PF, Davis S, Gladysheva T, Valtre C, Crenne JY, Mathieu M
J Mol Biol 423 439-53 (2012)
PMID: 22902478

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity nerve growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 300 amino acids
Theoretical weight: 33.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04629 (Residues: 498-796; Coverage: 39%)
Gene names: MTC, NTRK1, TRK, TRKA
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P41212
Unit cell:
a: 92.593Å b: 92.593Å c: 181.496Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.182 0.241
Expression system: Escherichia coli

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Citations

16 review citations

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives.
Zhong et al. (2021)
15 more

12 mentions without citation

Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.
Fu et al. (2013)
11 more