› 4f11

X-ray diffraction
2.38Å resolution

Crystal structure of the extracellular domain of human GABA(B) receptor GBR2

Released:
DOI: 10.2210/pdb4f11/pdb
PDB entry 4f11 coloured by chain, front view.
PDB entry 4f11 coloured by chain, side view.
PDB entry 4f11 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.
Geng Y, Xiong D, Mosyak L, Malito DL, Kniazeff J, Chen Y, Burmakina S, Quick M, Bush M, Javitch JA, Pin JP, Fan QR
Nat Neurosci 15 970-8 (2012)
PMID: 22660477

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131161 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-aminobutyric acid type B receptor subunit 2 Chain: A
Molecule details ›
Chain: A
Length: 433 amino acids
Theoretical weight: 49.13 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75899 (Residues: 42-466; Coverage: 47%)
Gene names: GABBR2, GPR51, GPRC3B
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 153.212Å b: 92.716Å c: 48.558Å
α: 90° β: 102.75° γ: 90°
R-values:
R R work R free
0.202 0.201 0.217
Expression system: Spodoptera frugiperda

Quick links

Citations

20 review citations

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.
Davenport et al. (2013)
19 more

24 mentions without citation

Molecular mechanisms of metabotropic GABAB receptor function.
Shaye et al. (2021)
23 more