› 4f2a

X-ray diffraction
3.11Å resolution

Crystal structure of cholestryl esters transfer protein in complex with inhibitors

Released:
DOI: 10.2210/pdb4f2a/pdb
PDB entry 4f2a coloured by chain, front view.
PDB entry 4f2a coloured by chain, side view.
PDB entry 4f2a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of cholesteryl ester transfer protein in complex with inhibitors.
Liu S, Mistry A, Reynolds JM, Lloyd DB, Griffor MC, Perry DA, Ruggeri RB, Clark RW, Qiu X
J Biol Chem 287 37321-9 (2012)
PMID: 22961980

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145884 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Cholesteryl ester transfer protein Chain: A
Molecule details ›
Chain: A
Length: 476 amino acids
Theoretical weight: 53.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P11597 (Residues: 18-493; Coverage: 100%)
Gene name: CETP
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, FUC
Carbohydrate polymer
5 bound ligands:
Ligand 2OB 2 x 2OB
Ligand PCW 1 x PCW
Ligand PGE 1 x PGE
Ligand CL 1 x CL
Ligand 0SF 1 x 0SF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P212121
Unit cell:
a: 68.772Å b: 69.915Å c: 187.145Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.183 0.239
Expression system: Cricetulus griseus

Quick links

Citations

7 review citations

Effects of cholesteryl ester transfer protein inhibitors on human lipoprotein metabolism: why have they failed in lowering coronary heart disease risk?
Schaefer EJ. (2013)
6 more

5 mentions without citation

Structure-based mechanism and inhibition of cholesteryl ester transfer protein.
Xue et al. (2023)
4 more