› 4f5w

X-ray diffraction
2.2Å resolution

Crystal structure of ligand free human STING CTD

Released:
DOI: 10.2210/pdb4f5w/pdb
PDB entry 4f5w coloured by chain, front view.
PDB entry 4f5w coloured by chain, side view.
PDB entry 4f5w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.
Shang G, Zhu D, Li N, Zhang J, Zhu C, Lu D, Liu C, Yu Q, Zhao Y, Xu S, Gu L
Nat Struct Mol Biol 19 725-7 (2012)
PMID: 22728660

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 239 amino acids
Theoretical weight: 27.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 149-379; Coverage: 61%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 81.099Å b: 91.028Å c: 73.395Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.275
Expression system: Escherichia coli

Quick links

Citations

65 review citations

Cyclic di-GMP: the first 25 years of a universal bacterial second messenger.
Römling et al. (2013)
64 more

7 mentions without citation

Activation of STING Based on Its Structural Features.
Hussain et al. (2022)
6 more