› 4f7h

X-ray diffraction
1.9Å resolution

The crystal structure of kindlin-2 pleckstrin homology domain in free form

Released:
DOI: 10.2210/pdb4f7h/pdb
PDB entry 4f7h coloured by chain, front view.
PDB entry 4f7h coloured by chain, side view.
PDB entry 4f7h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation.
Liu Y, Zhu Y, Ye S, Zhang R
Protein Cell 3 434-40 (2012)
PMID: 22653426

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fermitin family homolog 2 Chain: A
Molecule details ›
Chain: A
Length: 173 amino acids
Theoretical weight: 19.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96AC1 (Residues: 328-499; Coverage: 25%)
Gene names: FERMT2, KIND2, MIG2, PLEKHC1
Sequence domains:
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand SRT 2 x SRT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P43212
Unit cell:
a: 58.474Å b: 58.474Å c: 92.249Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.224
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Talins and kindlins: partners in integrin-mediated adhesion.
Calderwood et al. (2013)
3 more

4 mentions without citation

Defining the Domain Arrangement of the Mammalian Target of Rapamycin Complex Component Rictor Protein.
Zhou et al. (2015)
3 more