Function and Biology Details
Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Cyclin C-CDK8 complex (preferred)
PDBe Complex ID:
PDB-CPX-150300 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent kinase 8
Molecule details ›
Chain: A
Length: 405 amino acids
Theoretical weight: 46.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Protein kinase domain
Structure domains:
Length: 405 amino acids
Theoretical weight: 46.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P49336 (Residues: 1-403; Coverage: 87%)
Sequence domains: Protein kinase domain
Structure domains:
Cyclin-C
Molecule details ›
Chain: B
Length: 287 amino acids
Theoretical weight: 33.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Structure domains: Cyclin-like
Length: 287 amino acids
Theoretical weight: 33.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P24863 (Residues: 1-283; Coverage: 100%)
Sequence domains:
Structure domains: Cyclin-like
