› 4f80

X-ray diffraction
1.94Å resolution

Crystal Structure of the human BTN3A1 ectodomain

Released:
DOI: 10.2210/pdb4f80/pdb
PDB entry 4f80 coloured by chain, front view.
PDB entry 4f80 coloured by chain, side view.
PDB entry 4f80 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, Scotet E, Bonneville M, Adams EJ
J Biol Chem 287 32780-90 (2012)
PMID: 22846996

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126305 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Butyrophilin subfamily 3 member A1 Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 24.47 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O00481 (Residues: 30-246; Coverage: 45%)
Gene names: BTF5, BTN3A1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Unit cell:
a: 40.055Å b: 77.988Å c: 98.689Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.225 0.245
Expression system: Trichoplusia ni

Quick links

Citations

35 review citations

Six-of-the-best: unique contributions of γδ T cells to immunology.
Vantourout et al. (2013)
34 more

14 mentions without citation

An Update on the Molecular Basis of Phosphoantigen Recognition by Vγ9Vδ2 T Cells.
Herrmann et al. (2020)
13 more