› 4f9o

X-ray diffraction
2.65Å resolution

Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate

Released:
DOI: 10.2210/pdb4f9o/pdb
PDB entry 4f9o coloured by chain, front view.
PDB entry 4f9o coloured by chain, side view.
PDB entry 4f9o coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shen L, Honzatko RB

Function and Biology Details

Reaction catalysed: 
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 914 amino acids
Theoretical weight: 102.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19367 (Residues: 1-914; Coverage: 100%)
Gene name: HK1
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand BGC 4 x BGC
Ligand 0NZ 4 x 0NZ
Ligand NA 4 x NA
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 82.98Å b: 122.09Å c: 120.35Å
α: 90° β: 92.97° γ: 90°
R-values:
R R work R free
0.293 0.24 0.258
Expression system: Escherichia coli

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