4fa8

X-ray diffraction
2.2Å resolution

Multi-pronged modulation of cytokine signaling

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dodecamer (preferred)
homo hexamer
homo dimer
PDBe Complex ID:
PDB-CPX-140708 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Secreted protein BARF1 Chains: A, B, D
Molecule details ›
Chains: A, B, D
Length: 203 amino acids
Theoretical weight: 22.67 KDa
Source organism: human gammaherpesvirus 4
Expression system: Homo sapiens
UniProt:
  • Canonical: P0CW72 (Residues: 19-221; Coverage: 100%)
Gene name: BARF1
Structure domains: Immunoglobulins
Macrophage colony-stimulating factor 1 43 kDa subunit Chains: E, F, G
Molecule details ›
Chains: E, F, G
Length: 147 amino acids
Theoretical weight: 17.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09603 (Residues: 36-180; Coverage: 28%)
Gene name: CSF1
Sequence domains: Macrophage colony stimulating factor-1 (CSF-1)
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2
Unit cell:
a: 199.554Å b: 162.701Å c: 57.337Å
α: 90° β: 95.87° γ: 90°
R-values:
R R work R free
0.224 0.222 0.26
Expression system: Homo sapiens