› 4fgf

X-ray diffraction
1.6Å resolution

REFINEMENT OF THE STRUCTURE OF HUMAN BASIC FIBROBLAST GROWTH FACTOR AT 1.6 ANGSTROMS RESOLUTION AND ANALYSIS OF PRESUMED HEPARIN BINDING SITES BY SELENATE SUBSTITUTION

Released:
DOI: 10.2210/pdb4fgf/pdb
PDB entry 4fgf coloured by chain, front view.
PDB entry 4fgf coloured by chain, side view.
PDB entry 4fgf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Refinement of the structure of human basic fibroblast growth factor at 1.6 A resolution and analysis of presumed heparin binding sites by selenate substitution.
Eriksson AE, Cousens LS, Matthews BW
Protein Sci 2 1274-84 (1993)
PMID: 7691311

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140533 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 2 Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.44 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09038 (Residues: 143-288; Coverage: 51%)
Gene names: FGF2, FGFB
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand BME 2 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 30.9Å b: 33.4Å c: 35.9Å
α: 59.5° β: 72° γ: 75.6°
R-values:
R R work R free
0.161 not available not available
Expression system: Not provided

Quick links

Citations

3 review citations

Protein repeats: structures, functions, and evolution.
Andrade et al. (2001)
2 more

24 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
23 more