› 4fih

X-ray diffraction
1.97Å resolution

Catalytic domain of human PAK4 with QKFTGLPRQW peptide

Released:
DOI: 10.2210/pdb4fih/pdb
PDB entry 4fih coloured by chain, front view.
PDB entry 4fih coloured by chain, side view.
PDB entry 4fih coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ
Proc Natl Acad Sci U S A 109 16107-12 (2012)
PMID: 22988085

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 39.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 286-591; Coverage: 52%)
Gene names: KIAA1142, PAK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P41212
Unit cell:
a: 61.673Å b: 61.673Å c: 181.452Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.178 0.225
Expression system: Escherichia coli

Quick links

Citations

21 review citations

PAK signalling during the development and progression of cancer.
Radu et al. (2014)
20 more

1 mention without citation

PAK4 crystal structures suggest unusual kinase conformational movements.
Zhang et al. (2018)