› 4fo9

X-ray diffraction
2.39Å resolution

Crystal structure of the E3 SUMO Ligase PIAS2

Released:
DOI: 10.2210/pdb4fo9/pdb
PDB entry 4fo9 coloured by chain, front view.
PDB entry 4fo9 coloured by chain, side view.
PDB entry 4fo9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Hu J, Dobrovetsky E, Tempel W, Bountra C, Arrowsmith CH, Edwards AM, Tong Y, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131178 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 SUMO-protein ligase PIAS2 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 40.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O75928 (Residues: 147-488; Coverage: 55%)
Gene names: PIAS2, PIASX
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand UNX 20 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 90.288Å b: 170.14Å c: 57.507Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.257
Expression system: Escherichia coli BL21

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