› 4foi

X-ray diffraction
2.4Å resolution

Crystal Structure of recombinant human Hexokinase type I mutant D413N with Glucose 1,6-bisphosphate

Released:
DOI: 10.2210/pdb4foi/pdb
PDB entry 4foi coloured by chain, front view.
PDB entry 4foi coloured by chain, side view.
PDB entry 4foi coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shen L, Honzatko RB

Function and Biology Details

Reaction catalysed: 
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 917 amino acids
Theoretical weight: 102.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19367 (Residues: 1-917; Coverage: 100%)
Gene name: HK1
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand BGC 4 x BGC
Ligand G16 4 x G16
Ligand NA 4 x NA
Ligand CIT 2 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 82.38Å b: 120.772Å c: 120.591Å
α: 90° β: 92.8° γ: 90°
R-values:
R R work R free
0.273 0.247 0.273
Expression system: Escherichia coli

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