› 4fss

X-ray diffraction
2.25Å resolution

Crystal structure of a RAS p21 protein activator (RASA1) from Homo sapiens at 2.25 A resolution

Released:
DOI: 10.2210/pdb4fss/pdb
PDB entry 4fss coloured by chain, front view.
PDB entry 4fss coloured by chain, side view.
PDB entry 4fss coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras GTPase-activating protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 62 amino acids
Theoretical weight: 7.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20936 (Residues: 281-341; Coverage: 6%)
Gene names: GAP, RASA, RASA1
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

3 bound ligands:
Ligand PO4 1 x PO4
Ligand CL 3 x CL
Ligand GOL 1 x GOL
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P6122
Unit cell:
a: 82.22Å b: 82.22Å c: 157.212Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.213 0.237
Expression system: Escherichia coli

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