› 4fv9

X-ray diffraction
2.11Å resolution

Crystal Structure of the ERK2 complexed with E71

Released:
DOI: 10.2210/pdb4fv9/pdb
PDB entry 4fv9 coloured by chain, front view.
PDB entry 4fv9 coloured by chain, side view.
PDB entry 4fv9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kang YN, Stuckey JA, Xie X

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 41.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand E71 1 x E71
Ligand SO4 5 x SO4
Ligand EDO 1 x EDO
1 modified residue:
Ligand CME 1 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 43.96Å b: 70.66Å c: 120Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.238
Expression system: Escherichia coli

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