› 4g1e

X-ray diffraction
3Å resolution

Crystal structure of integrin alpha V beta 3 with coil-coiled tag.

Released:
DOI: 10.2210/pdb4g1e/pdb
PDB entry 4g1e coloured by chain, front view.
PDB entry 4g1e coloured by chain, side view.
PDB entry 4g1e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
α(V)β(3) integrin crystal structures and their functional implications.
Dong X, Mi LZ, Zhu J, Wang W, Hu P, Luo BH, Springer TA
Biochemistry 51 8814-28 (2012)
PMID: 23106217

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
homo dimer
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-138434 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (8 distinct):
Integrin alpha-V Chain: A
Molecule details ›
Chain: A
Length: 998 amino acids
Theoretical weight: 110.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06756 (Residues: 31-989; Coverage: 94%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Structure domains:
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 738 amino acids
Theoretical weight: 81.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05106 (Residues: 27-717; Coverage: 91%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
5 bound ligands:
Ligand CA 6 x CA
Ligand NAG 2 x NAG
Ligand SO4 6 x SO4
Ligand CL 7 x CL
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P3221
Unit cell:
a: 128.558Å b: 128.558Å c: 352.859Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.242 0.241 0.261
Expression system: Not provided

Quick links

Citations

9 review citations

Talins and kindlins: partners in integrin-mediated adhesion.
Calderwood et al. (2013)
8 more

10 mentions without citation

α(V)β(3) integrin crystal structures and their functional implications.
Dong et al. (2012)
9 more