Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Integrin alphav-beta3 complex (preferred)
PDBe Complex ID:
PDB-CPX-138434 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Integrin alpha-V
Molecule details ›
Chain: A
Length: 959 amino acids
Theoretical weight: 106.05 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains:
Length: 959 amino acids
Theoretical weight: 106.05 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P06756 (Residues: 31-989; Coverage: 94%)
Sequence domains:
- FG-GAP repeat
- Integrin alpha Ig-like domain 1
- Integrin alpha Ig-like domain 2
- Integrin alpha Ig-like domain 3
Integrin beta-3
Molecule details ›
Chain: B
Length: 692 amino acids
Theoretical weight: 76.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains:
Length: 692 amino acids
Theoretical weight: 76.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical: P05106 (Residues: 27-718; Coverage: 91%)
Sequence domains:
- Integrin plexin domain
- Integrin beta chain VWA domain
- Integrin beta epidermal growth factor like domain 1
- EGF-like domain
- Integrin beta tail domain
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 19-ID
Spacegroup:
P3221
Expression system: Cricetulus griseus
