› 4g1t

X-ray diffraction
2.8Å resolution

Crystal structure of interferon-stimulated gene 54

Released:
DOI: 10.2210/pdb4g1t/pdb
PDB entry 4g1t coloured by chain, front view.
PDB entry 4g1t coloured by chain, side view.
PDB entry 4g1t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.
Yang Z, Liang H, Zhou Q, Li Y, Chen H, Ye W, Chen D, Fleming J, Shu H, Liu Y
Cell Res 22 1328-38 (2012)
PMID: 22825553

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced protein with tetratricopeptide repeats 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 472 amino acids
Theoretical weight: 54.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09913 (Residues: 1-472; Coverage: 100%)
Gene names: CIG-42, G10P2, IFI54, IFIT2, ISG54
Sequence domains: Tetratricopeptide repeat
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U, PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P212121
Unit cell:
a: 80.023Å b: 95.207Å c: 155.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.287
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Interferon-induced Ifit proteins: their role in viral pathogenesis.
Fensterl et al. (2015)
15 more

8 mentions without citation

The broad-spectrum antiviral functions of IFIT and IFITM proteins.
Diamond et al. (2013)
7 more