› 4g82

X-ray diffraction
3.1Å resolution

Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element

Released:
DOI: 10.2210/pdb4g82/pdb
PDB entry 4g82 coloured by chain, front view.
PDB entry 4g82 coloured by chain, side view.
PDB entry 4g82 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element
Ethayathulla AS, Viadiu H
J. Biol. Chem. (2013)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117534 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Tumor protein p73 Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15350 (Residues: 115-312; Coverage: 31%)
Gene names: P73, TP73
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like
DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3') Chains: E, F
Molecule details ›
Chains: E, F
Length: 10 nucleotides
Theoretical weight: 3.04 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P61
Unit cell:
a: 175.472Å b: 175.472Å c: 34.317Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.238 0.268
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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