› 4ga7

X-ray diffraction
2.9Å resolution

Crystal structure of human serpinB1 mutant

Released:
DOI: 10.2210/pdb4ga7/pdb
PDB entry 4ga7 coloured by chain, front view.
PDB entry 4ga7 coloured by chain, side view.
PDB entry 4ga7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of SERPINB1 as a physiological inhibitor of human granzyme H.
Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z
J Immunol 190 1319-30 (2013)
PMID: 23269243

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukocyte elastase inhibitor Chains: A, B
Molecule details ›
Chains: A, B
Length: 389 amino acids
Theoretical weight: 43.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30740 (Residues: 1-379; Coverage: 100%)
Gene names: ELANH2, MNEI, PI2, SERPINB1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P41
Unit cell:
a: 67.339Å b: 67.339Å c: 180.288Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.183 0.232
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Granzyme M: behind enemy lines.
de Poot et al. (2014)
2 more

2 mentions without citation

A Comprehensive Phylogenetic Analysis of the Serpin Superfamily.
Spence et al. (2021)
1 more