Function and Biology Details
Reaction catalysed:
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158200 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DCN1-like protein 2
Molecule details ›
Chains: A, B, D, G
Length: 200 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Cullin binding
Structure domains:
Length: 200 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q6PH85 (Residues: 62-259; Coverage: 76%)
Sequence domains: Cullin binding
Structure domains:
NEDD8-conjugating enzyme Ubc12
Molecule details ›
Chains: C, E, F, H
Length: 12 amino acids
Theoretical weight: 1.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 12 amino acids
Theoretical weight: 1.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P61081 (Residues: 1-12; Coverage: 7%)
