› 4ge4

X-ray diffraction
2.41Å resolution

Function and Biology Details

Reactions catalysed: 
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
Glycine + 2-oxoglutarate = glyoxylate + L-glutamate
(1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine 
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 439 amino acids
Theoretical weight: 48.95 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8N5Z0 (Residues: 1-425; Coverage: 100%)
Gene names: AADAT, KAT2, KYAT2
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 0KE 2 x 0KE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3221
Unit cell:
a: 111.944Å b: 111.944Å c: 137.508Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.187 0.213
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Major Developments in the Design of Inhibitors along the Kynurenine Pathway.
Jacobs et al. (2017)
1 more

2 mentions without citation

The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue.
Rossi et al. (2019)
1 more