› 4geh

X-ray diffraction
1.95Å resolution

Crystal structure of MST4 dimerization domain complex with PDCD10

Released:
DOI: 10.2210/pdb4geh/pdb
PDB entry 4geh coloured by chain, front view.
PDB entry 4geh coloured by chain, side view.
PDB entry 4geh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism of CCM3 heterodimerization with GCKIII kinases.
Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q, Wang W, Yin M, Zhao Y, Zhang L, Zhou Z
Structure 21 680-8 (2013)
PMID: 23541896

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189739 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Programmed cell death protein 10 Chains: A, C
Molecule details ›
Chains: A, C
Length: 207 amino acids
Theoretical weight: 23.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BUL8 (Residues: 9-212; Coverage: 96%)
Gene names: CCM3, PDCD10, TFAR15
Sequence domains:
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)
Serine/threonine-protein kinase 26 Chains: B, D
Molecule details ›
Chains: B, D
Length: 91 amino acids
Theoretical weight: 10.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P289 (Residues: 325-413; Coverage: 21%)
Gene names: MASK, MST4, STK26
Sequence domains: Programmed cell death protein 10, dimerisation domain
Structure domains: Lyase 2-enoyl-coa Hydratase; Chain A, domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 75.243Å b: 84.018Å c: 109.679Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.253
Expression system: Escherichia coli

Quick links

Citations

13 review citations

STRIPAK complexes: structure, biological function, and involvement in human diseases.
Hwang et al. (2014)
12 more

2 mentions without citation

Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex.
Chen et al. (2014)
1 more