› 4geo

X-ray diffraction
1.66Å resolution

P38a MAP kinase DEF-pocket penta mutant (M194A, L195A, H228A, I229A, Y258A)

Released:
DOI: 10.2210/pdb4geo/pdb
PDB entry 4geo coloured by chain, front view.
PDB entry 4geo coloured by chain, side view.
PDB entry 4geo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Livnah O, Tzarum N

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 41.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BOG 2 x BOG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 66.937Å b: 74.658Å c: 74.802Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.255
Expression system: Escherichia coli BL21(DE3)

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