› 4gga

X-ray diffraction
2.04Å resolution

Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C

Released:
DOI: 10.2210/pdb4gga/pdb
PDB entry 4gga coloured by chain, front view.
PDB entry 4gga coloured by chain, side view.
PDB entry 4gga coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Tian W, Li B, Warrington R, Tomchick DR, Yu H, Luo X
Proc Natl Acad Sci U S A 109 18419-24 (2012)
PMID: 23091007

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171409 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division cycle protein 20 homolog Chain: A
Molecule details ›
Chain: A
Length: 420 amino acids
Theoretical weight: 46.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12834 (Residues: 81-499; Coverage: 84%)
Gene name: CDC20
Sequence domains:
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 40.865Å b: 87.258Å c: 110.954Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.151 0.203
Expression system: Spodoptera frugiperda

Quick links

Citations

18 review citations

Ubiquitin Ligases: Structure, Function, and Regulation.
Zheng et al. (2017)
17 more

6 mentions without citation

The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation.
Lee et al. (2014)
5 more