Function and Biology Details
Reaction catalysed:
Exonucleolytic cleavage of poly(A) to 5'-AMP
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
CCR4-NOT transcription complex (preferred)
PDBe Complex ID:
PDB-CPX-107794 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CCR4-NOT transcription complex subunit 1
Molecule details ›
Chains: A, C, E
Length: 229 amino acids
Theoretical weight: 26.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: CCR4-NOT transcription complex subunit 1 CAF1-binding domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Length: 229 amino acids
Theoretical weight: 26.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
A5YKK6 (Residues: 1093-1317; Coverage: 10%)
Sequence domains: CCR4-NOT transcription complex subunit 1 CAF1-binding domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
CCR4-NOT transcription complex subunit 7
Molecule details ›
Chains: B, D, F
Length: 285 amino acids
Theoretical weight: 32.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: CAF1 family ribonuclease
Structure domains: Ribonuclease H-like superfamily/Ribonuclease H
Length: 285 amino acids
Theoretical weight: 32.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9UIV1 (Residues: 1-285; Coverage: 100%)
Sequence domains: CAF1 family ribonuclease
Structure domains: Ribonuclease H-like superfamily/Ribonuclease H
