› 4gub

X-ray diffraction
2.2Å resolution

Casein Kinase II bound to Inhibitor

Released:
DOI: 10.2210/pdb4gub/pdb
PDB entry 4gub coloured by chain, front view.
PDB entry 4gub coloured by chain, side view.
PDB entry 4gub coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Larsen NA, Dowling JE

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 333 amino acids
Theoretical weight: 39.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-333; Coverage: 85%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 0Y4 1 x 0Y4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21212
Unit cell:
a: 77.637Å b: 141.728Å c: 49.112Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.238
Expression system: Escherichia coli

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