› 4gwf

X-ray diffraction
2.1Å resolution

Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation

Released:
DOI: 10.2210/pdb4gwf/pdb
PDB entry 4gwf coloured by chain, front view.
PDB entry 4gwf coloured by chain, side view.
PDB entry 4gwf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Qiu W, Lin A, Hutchinson A, Romanov V, Ruzanov M, Thompson C, Lam K, Kisselman G, Battaile K, Chirgadze NY

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 560 amino acids
Theoretical weight: 64.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 1-539; Coverage: 91%)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand EDO 15 x EDO
Ligand GOL 1 x GOL
Ligand PEG 2 x PEG
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 45.972Å b: 211.953Å c: 55.691Å
α: 90° β: 96.63° γ: 90°
R-values:
R R work R free
0.211 0.21 0.243
Expression system: Escherichia coli

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