› 4h1o

X-ray diffraction
2.2Å resolution

Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation

Released:
DOI: 10.2210/pdb4h1o/pdb
PDB entry 4h1o coloured by chain, front view.
PDB entry 4h1o coloured by chain, side view.
PDB entry 4h1o coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Qiu W, Lin A, Hutchinson A, Romanov V, Ruzanov M, Thompson C, Lam K, Kisselman G, Battaile K, Chirgadze NY

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chain: A
Molecule details ›
Chain: A
Length: 560 amino acids
Theoretical weight: 64.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 1-539; Coverage: 91%)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21212
Unit cell:
a: 54.979Å b: 220.277Å c: 41.648Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.21 0.233
Expression system: Escherichia coli

Quick links