› 4hag

X-ray diffraction
3.4Å resolution

Crystal structure of fc-fragment of human IgG2 antibody (centered crystal form)

Released:
DOI: 10.2210/pdb4hag/pdb
PDB entry 4hag coloured by chain, front view.
PDB entry 4hag coloured by chain, side view.
PDB entry 4hag coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
IgG2 Fc structure and the dynamic features of the IgG CH2-CH3 interface.
Teplyakov A, Zhao Y, Malia TJ, Obmolova G, Gilliland GL
Mol Immunol 56 131-9 (2013)
PMID: 23628091

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134881 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 2 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 25.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01859 (Residues: 104-324; Coverage: 56%)
Gene name: IGHG2
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2221
Unit cell:
a: 52.24Å b: 144.4Å c: 75.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.301 0.299 0.349
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Type I and type II Fc receptors regulate innate and adaptive immunity.
Pincetic et al. (2014)
10 more

5 mentions without citation

IgG Fc engineering to modulate antibody effector functions.
Wang et al. (2018)
4 more