› 4hgm

X-ray diffraction
2.34Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136179 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Shark V-NAR Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.36 KDa
Source organism: Squalus acanthias
Expression system: Chlorocebus aethiops
Structure domains: Immunoglobulins
Albumin Chain: B
Molecule details ›
Chain: B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand ACE 1 x ACE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3121
Unit cell:
a: 131.335Å b: 131.335Å c: 74.519Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.221 0.259
Expression systems:
  • Chlorocebus aethiops
  • Escherichia coli

Quick links

Citations

25 review citations

Antibody Structure and Function: The Basis for Engineering Therapeutics.
Chiu et al. (2019)
24 more

5 mentions without citation

Non-covalent albumin-binding ligands for extending the circulating half-life of small biotherapeutics.
Zorzi et al. (2019)
4 more