› 4hgt

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 34.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48730 (Residues: 1-294; Coverage: 71%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 15G 2 x 15G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: P21
Unit cell:
a: 49.17Å b: 72.97Å c: 89.33Å
α: 90° β: 103.63° γ: 90°
R-values:
R R work R free
0.24 0.24 not available
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Casein kinases as potential therapeutic targets.
Cozza et al. (2016)
2 more

7 mentions without citation

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.
Knippschild et al. (2014)
6 more