› 4hi9

X-ray diffraction
1.2Å resolution

1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974

Released:
DOI: 10.2210/pdb4hi9/pdb
PDB entry 4hi9 coloured by chain, front view.
PDB entry 4hi9 coloured by chain, side view.
PDB entry 4hi9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Stiegler AL, Jakoncic J, Stojanoff V, Chiswell BP, Calderwood DA, Boggon TJ

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155700 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin-linked protein kinase Chain: A
Molecule details ›
Chain: A
Length: 179 amino acids
Theoretical weight: 20.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13418 (Residues: 1-174; Coverage: 39%)
Gene names: ILK, ILK1, ILK2
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain
LIM and senescent cell antigen-like-containing domain protein 1 Chain: B
Molecule details ›
Chain: B
Length: 72 amino acids
Theoretical weight: 8.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48059 (Residues: 6-68; Coverage: 19%)
Gene names: LIMS1, PINCH, PINCH1
Sequence domains: LIM domain
Structure domains: Cysteine Rich Protein

Ligands and Environments

3 bound ligands:
Ligand PO4 1 x PO4
Ligand IOD 10 x IOD
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P1
Unit cell:
a: 37.144Å b: 41.775Å c: 46.798Å
α: 78.67° β: 68.94° γ: 85.81°
R-values:
R R work R free
0.176 0.175 0.198
Expression system: Escherichia coli

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