Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Amyloid-beta protein 40/42 complex (preferred)
PDBe Complex ID:
PDB-CPX-134616 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy constant gamma 1
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Length: 227 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
P01857 (Residues: 1-107; Coverage: 27%)
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunoglobulin kappa constant
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Length: 220 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
P3(42)
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 3.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Beta-amyloid peptide (beta-APP)
Length: 28 amino acids
Theoretical weight: 3.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P05067 (Residues: 672-699; Coverage: 4%)
Sequence domains: Beta-amyloid peptide (beta-APP)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Expression system: Not provided
