› 4hkd

X-ray diffraction
1.5Å resolution

Crystal structure of human MST2 SARAH domain

Released:
DOI: 10.2210/pdb4hkd/pdb
PDB entry 4hkd coloured by chain, front view.
PDB entry 4hkd coloured by chain, side view.
PDB entry 4hkd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Liu GG, Shi ZB, Zhou ZC

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171593 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 3 20kDa subunit Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 53 amino acids
Theoretical weight: 6.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13188 (Residues: 436-484; Coverage: 10%)
Gene names: KRS1, MST2, STK3
Sequence domains: C terminal SARAH domain of Mst1
Structure domains: p53-like tetramerisation domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 20 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 42.205Å b: 44.615Å c: 209.155Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.23
Expression system: Escherichia coli

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