Function and Biology Details
Reaction catalysed:
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
- Aminopeptidase N-type
- Aminopeptidase N-like , N-terminal domain superfamliy
- Tachykinin/Neurokinin-like, conserved site
- Tachykinin domain
- ERAP1-like C-terminal domain
- Peptidase M1, membrane alanine aminopeptidase
- Peptidase M4/M1, CTD superfamily
1 more domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Aminopeptidase N and Neuropeptide K (preferred)
PDBe Complex ID:
PDB-CPX-147241 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Aminopeptidase N
Molecule details ›
Chain: A
Length: 908 amino acids
Theoretical weight: 103.52 KDa
Source organism: Sus scrofa
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Structure domains:
Length: 908 amino acids
Theoretical weight: 103.52 KDa
Source organism: Sus scrofa
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P15145 (Residues: 63-963; Coverage: 94%)
Sequence domains:
Structure domains:
Substance P
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Tachykinin family
Length: 11 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P20366 (Residues: 58-68; Coverage: 10%)
Sequence domains: Tachykinin family
Ligands and Environments
Experiments and Validation Details
X-ray source:
APS BEAMLINE 19-ID
Spacegroup:
C2
Expression systems:
- Spodoptera frugiperda
- Not provided
