› 4hou

X-ray diffraction
1.95Å resolution

Crystal Structure of N-terminal Human IFIT1

Released:
DOI: 10.2210/pdb4hou/pdb
PDB entry 4hou coloured by chain, front view.
PDB entry 4hou coloured by chain, side view.
PDB entry 4hou coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.
Abbas YM, Pichlmair A, Górna MW, Superti-Furga G, Nagar B
Nature 494 60-4 (2013)
PMID: 23334420

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140806 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced protein with tetratricopeptide repeats 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 273 amino acids
Theoretical weight: 31.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09914 (Residues: 7-279; Coverage: 57%)
Gene names: G10P1, IFI56, IFIT1, IFNAI1, ISG56
Sequence domains:
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2
Unit cell:
a: 84.47Å b: 176.952Å c: 55.143Å
α: 90° β: 130.13° γ: 90°
R-values:
R R work R free
0.204 0.202 0.232
Expression system: Escherichia coli

Quick links

Citations

39 review citations

Newly described pattern recognition receptors team up against intracellular pathogens.
Broz et al. (2013)
38 more

8 mentions without citation

IFITs: Emerging Roles as Key Anti-Viral Proteins.
Vladimer et al. (2014)
7 more