› 4hr9

X-ray diffraction
2.48Å resolution

Human interleukin 17A

Released:
DOI: 10.2210/pdb4hr9/pdb
PDB entry 4hr9 coloured by chain, front view.
PDB entry 4hr9 coloured by chain, side view.
PDB entry 4hr9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of interleukin 17A and its complex with IL-17 receptor A.
Liu S, Song X, Chrunyk BA, Shanker S, Hoth LR, Marr ES, Griffor MC
Nat Commun 4 1888 (2013)
PMID: 23695682

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172495 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-17A Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 14.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16552 (Residues: 34-155; Coverage: 92%)
Gene names: CTLA8, IL17, IL17A
Sequence domains: Interleukin-17
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2221
Unit cell:
a: 64.35Å b: 85.25Å c: 119.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.21 0.233
Expression system: Homo sapiens

Quick links

Citations

18 review citations

IL-17 family: cytokines, receptors and signaling.
Gu et al. (2013)
17 more

9 mentions without citation

Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines.
Ott et al. (2018)
8 more