› 4hs2

X-ray diffraction
1.53Å resolution

Crystal Structure of the Human SPOP C-terminal Domain

Released:
DOI: 10.2210/pdb4hs2/pdb
PDB entry 4hs2 coloured by chain, front view.
PDB entry 4hs2 coloured by chain, side view.
PDB entry 4hs2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP.
van Geersdaele LK, Stead MA, Harrison CM, Carr SB, Close HJ, Rosbrook GO, Connell SD, Wright SC
Acta Crystallogr D Biol Crystallogr 69 1677-84 (2013)
PMID: 23999291

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Speckle-type POZ protein Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 11.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43791 (Residues: 270-374; Coverage: 28%)
Gene name: SPOP
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1, DIAMOND BEAMLINE I02
Spacegroup: P6122
Unit cell:
a: 57.65Å b: 57.65Å c: 102.81Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.133 0.132 0.151
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.
Bulatov et al. (2015)
8 more

4 mentions without citation

The ubiquitin ligase adaptor SPOP in cancer.
Cuneo et al. (2019)
3 more